About SpringWorks TherapeuticsSpringWorks is a clinical-stage biopharmaceutical company applying a precision medicine approach to acquiring, developing and commercializing life-changing medicines for patients living with severe rare diseases and cancer. SpringWorks has a differentiated targeted oncology pipeline spanning solid tumors and hematological cancers, including two late-stage clinical trials in rare tumor types as well as several programs addressing highly prevalent, genetically defined cancers.

SpringWorks' strategic approach and operational excellence in clinical development have enabled it to rapidly advance its two lead product candidates into late-stage clinical trials while simultaneously entering into multiple shared-value partnerships with innovators in industry and academia to unlock the full potential for its portfolio and create more solutions for patients with cancer. We give it our all every day because we believe in the power of targeted oncology to help people with cancer. If you recognize yourself in us, then we'd like to meet you.

The answers are waiting - and we need your help finding them. About the Role:The Discovery Chemistry Principal Scientist, will serve as a senior chemist on project teams, contributing synthetic and medicinal chemistry advances to progress projects from hit identification. Reporting to Director of Discovery Chemistry, the Discovery Chemistry Principal Scientist will serve as a senior chemist on project teams, contributing synthetic and medicinal chemistry advances to progress projects from hit identification through nomination of development candidates.

This role will foster a culture of scientific excellence, rigorous innovation, collaboration, and teamwork. This individual will have significant experience in the pharmaceutical industry and a track record of scientific achievement, ideally having identified development candidates. This individual will be expected to train, supervise and mentor internal medicinal chemists and may direct the activities of CRO partners.

Responsibilities Include:Develop SAR for drug discovery programs and collaborate with project leaders to drive small molecule programs from HTS through development candidate nomination.Serve as a departmental expert in analyzing, interpreting and visualizing scientific data.May manage internal and external (contract research organization) resources to deliver high quality compounds in an efficient manner.

Design and execute complex chemical syntheses to deliver high quality molecules for biological assays.Develop new intellectual property and co-author patent applications and peer-reviewed publications.Identify, develop, and evaluate new technologies to enhance productivity and efficiency across the chemistry department.

Partner with structural biologists, computational scientists and related disciplines to design novel small molecules to achieve program objectives.Oversee preparation of key findings and present at scientific meetings, conferences and to internal/external stakeholders.Model SpringWorks Values to drive a collaborative function that embraces change and drives excellence.

Perform other duties and responsibilities as assigned.About You: Required Education, Skills, and ExperienceEducation: Ph.D. in synthetic organic chemistry or related scientific discipline plus 12+ years' experience or Masters Degree in synthetic organic chemistry or related scientific discipline plus 15+ years' experience.

Direct people management experience required.Medicinal chemistry experience in biotech/pharma; ideally, as a key contributor in the identification of compounds that have entered pre-clinical development.Deep knowledge of synthetic organic and medicinal chemistry disciplines Demonstrated proficiency in the synthesis of small molecules Advanced knowledge and experience training others in use of laboratory equipment (eg, LCMS, HPLC, Flash Chromatography, NMR, microwave) Demonstrated proficiency in solving medicinal chemistry challenges Strong knowledge of protein-ligand interactions and application of this knowledge in Structure-Based Drug Design (SBDD) Expertise in the interpretation, analysis, documentation, and presentation of key findings Effective training, mentoring and professional development of more junior staff Ability to take initiative and lead other laboratory scientists by example and influence Experience supervising laboratory work and personnel to ensure safe laboratory practices Ability to manage CRO and internal teams to maximize productivity Effective organizational, interpersonal, communication and managerial skills Excellent written and oral communication skills Ability to communicate technical and cross-functional data to diverse audiences Creates networks with key decision makers to influence company scientific strategy This position is laboratory based and may be required to be on-site up to 5 days a week.Relocation available.

The expected salary range for this position is $152,250.00 - $200,000.00. Actual pay will be determined based on experience, qualifications, location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance.

We also offer a comprehensive benefits package for our team of SpringWorkers and their families, including competitive compensation, annual cash bonuses and equity grants, 401K matching, fully covered medical, dental, and vision plans, and a full week of holiday break at year end. It's the right thing to do - and helps us be healthy, happy, and at our best for the people who need us.At SpringWorks, we believe in fostering a culture of belonging.

Our Employee Resource Group's (ERG) mission is to boldly live the SpringWorks values, provide resources, and deeply engage SpringWorkers and the communities we serve to foster a culture of belonging. Ensuring diversity, equity, and inclusion are integral to our organization's DNA. SpringWorks maintains an EEO Policy providing for equitable opportunities for employment and conditions of employment to all employees and applicants regardless of actual or perceived sex (including pregnancy, childbirth, breastfeeding or related medical conditions), gender, gender identity or gender expression, sexual orientation, partnership status, marital status, familial status, pregnancy status, race, color, national origin, ancestry, caste, religion, religious creed, age, alienage or citizenship status, veteran status, military status, physical or mental disability, past or present history of mental disorder, medical condition, AIDS/HIV status, sickle cell or hemoglobin C trait, genetic predisposition, genetic information, protected medical leaves, victims of domestic violence, stalking, or sex offense, political affiliation and any and all other characteristics or categories protected by applicable federal, state or local laws.

SpringWorks treats all employees and applicants fairly in the selection process (and in other personnel activities) by giving all employees and applicants the same opportunities for employment. SpringWorks' Equal Employment Opportunity Policy is intended to ensure that there are no barriers that would prevent members of a protected group from a fair and equitable opportunity to be hired, promoted, or to otherwise take advantage of employment opportunities.This Equal Employment Opportunity Policy applies to all aspects of employment, including, without limitation, recruitment, hiring, placement, job assignment, promotion, termination, transfer, leaves of absence, compensation, discipline, and access to benefits and training.

Any violation of this Policy will result in disciplinary action up to and including termination of employment.GDPR Statement: When you apply to a job on this site, the personal data contained in your application will be collected by SpringWorks Therapeutics ( Controller ), which is located at 100 Washington Blvd, Stamford CT 6902 and can be contacted by emailing hr@springworkstx.com . Your personal data will be processed for the purposes of managing Controller's recruitment related activities, which include setting up and conducting interviews and tests for applicants, evaluating and assessing the results thereto, and as is otherwise needed in the recruitment and hiring processes.

Such processing is legally permissible under Art. 6(1)(f) of Regulation (EU) 2016/679 (General Data Protection Regulation) as necessary for the purposes of the legitimate interests pursued by the Controller, which are the solicitation, evaluation, and selection of applicants for employment.Your personal data will be shared with Greenhouse Software, Inc.

, a cloud services provider located in the United States of America and engaged by Controller to help manage its recruitment and hiring process on Controller's behalf. Accordingly, if you are located outside of the United States, your personal data will be transferred to the United States once you submit it through this site. Because the European Union Commission has determined that United States data privacy laws do not ensure an adequate level of protection for personal data collected from EU data subjects, the transfer will be subject to appropriate additional safeguards under the standard contractual clauses.

You can obtain a copy of the standard contractual clauses by contacting us at hr@springworkstx.com.Your personal data will be retained by Controller for as long as Controller determines it is necessary to evaluate your application for employment. Under the GDPR, you have the right to request access to your personal data, to request that your personal data be rectified or erased, and to request that processing of your personal data be restricted.

You also have to right to data portability. In addition, you may lodge a complaint with an EU supervisory authority